Pentylenetetrazole-induced seizures in developing rats prenatally exposed to valproic acid
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چکیده
منابع مشابه
Pentylenetetrazole-induced seizures in developing rats prenatally exposed to valproic acid
BACKGROUND Epidemiological evidence indicates epilepsy is more common in patients with autism spectrum disorders (ASD) (20-25%) than in the general population. The aim of this project was to analyze seizure susceptibility in developing rats prenatally exposed to valproic acid (VPA) as autism model. METHODS Pregnant females were injected with VPA during the twelfth embryonic day. Seizures were...
متن کاملDevelopmental disruption of amygdala transcriptome and socioemotional behavior in rats exposed to valproic acid prenatally
BACKGROUND The amygdala controls socioemotional behavior and has consistently been implicated in the etiology of autism spectrum disorder (ASD). Precocious amygdala development is commonly reported in ASD youth with the degree of overgrowth positively correlated to the severity of ASD symptoms. Prenatal exposure to VPA leads to an ASD phenotype in both humans and rats and has become a commonly ...
متن کاملGross hepatic changes in developing albino rats exposed to valproic acid.
BACKGROUND Valproid Acid (VPA) is a broad spectrum antiepileptic drug. Its use during pregnancy has been associated with congenital anomalies and hepatotoxicity. This study was designed to assess the effects of VPA on the gross structure of liver in developing albino rats exposed to the drug during various trimesters of pregnancy. METHODS In this experimental study 40 pregnant rats were divid...
متن کاملP54: Anti-Apoptotic Effect of Neural Regeneration Peptides (NRP) 2945 on Pentylenetetrazole-Induced Seizures in Rats
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متن کاملEvaluation of Anticonvulsant Effects of Nimodipine and Ascorbic Acid on Pentylenetetrazole- Induced Seizures in Mice
Introduction: The mechanisms underlying the vulnerability of the brain to seizures remains unknown. Calcium ions influx and oxidative stress have been implicated in a variety of acute and chronic epileptogenic conditions. The present study was aimed at investigating the effects of nimodipine and ascorbic acid (vitamin C) alone and in combination on pentylenetetrazole (PTZ) - induced seizures ...
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ژورنال
عنوان ژورنال: PeerJ
سال: 2016
ISSN: 2167-8359
DOI: 10.7717/peerj.2709